Rosuvastatin relaxes rat thoracic aorta, pulmonary artery, and trachea via nitric oxide, prostanoids, and potassium channels

Purpose: This study aimed to determine the functional effects and mechanisms of action rosuvastatin on vascular tracheal smooth muscle tissues. 
 Materials Methods: Vascular rings (2-3 mm) isolated from thoracic aortas, pulmonary arteries, tracheas Wistar Albino male rats (250-300 g) were placed in chambers tissue bath system. As resting tension, 1 g was selected. contracted with 10-6 M phenylephrine after a 90-minute equilibration period. Tracheal 10-5 acetylcholine. After contraction steady, (10-8-10-4 M) cumulatively applied rings. The defined experimental methodology repeated following incubation selective inhibitors signaling pathways K+ channel blockers ascertain rosuvastatin's effect mechanisms. Results: In precontracted rat rings, induced concentration-dependent relaxation. maximal relaxation level vessel samples 96%. On other hand, found be 75%. vasorelaxant dramatically attenuated by endothelium removal, L-NAME treatment, indomethacin (up 27%). With tetraethylammonium, glyburide, 4-Aminopyridine, anandamide, rosuvastatin-mediated levels significantly decreased 38%). Moreover, 4-Aminopyridine 30%). Conclusion: Rosuvastatin has noticeable relaxing muscles. involves intact endothelium, nitric oxide, prostanoids, channels (BKCa, KV, KATP channels). Furthermore, BKCa channels, KV play role rosuvastatin-induced